![]() The present results suggest that the morphologically distinct, subclasses of PSDC neurons in spinal laminae III and IV may contribute to the central transmission of mechanical nociceptive information through the dorsal column into the cuneate nucleus. discriminative responses to cutaneous and deep sensory stimuli. Most of the double-labeled neurons appeared fusiform with their primary dendrites projected dorso-ventrally. A review of the literature supporting a hypothesis that spinal cord stimulation (SCS) might work by modulating information through the spinothalamic tracts (STT) and PSDC is presented. The dorsal column has previously been known solely as a direct pathway for primary afferent fiber transmission of epicritic information, e.g. At segment C6 or C7, double-labeled neurons made up about 10 % of the PSDC neurons that projected their axons to the cuneate nucleus. The failure of pinch-responssive PSDC cells to respond to thermal stimulation, even in sensitized skin, suggests that they do not receive a functionally significant input from C polymodal nociceptors, heat nociceptors, or mechanical-heat nociceptors. In the rats subjected to the noxious pinch coupled with FG injection into the right cuneate nucleus, PSDC neurons double labeled with Fos and FG were localized in the ipsilateral laminae III and IV extending from segment C5 to T1, with about 70 % of them distributed at segments C6 and C7. Between segments C5 and T1, about 40 % of the Fos-LI neurons in laminae III and IV were distributed at segment C7. After repeated noxious pinching of the forepaw glabrous area, there was a marked increase in number of Fos-LI neurons in the dorsal horn, including Rexed's laminae III and IV, at C5-T1 spinal cord segments ipsilateral to the stimulation. For this purpose, Fos immunohistochemistry along with Fluoro-Gold (FG) retrograde tracing was utilized. ![]() This study was conducted to ascertain the possible expression of Fos-like immunoreactivity (Fos-LI) in the postsynaptic dorsal column (PSDC) neurons in response to noxious mechanical stimulation of the forepaw glabrous area of normal rats. ![]()
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